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Analyses of neuronal ensemble interactions

Research Project

Project/Area Number 15K14314
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Research InstitutionOsaka University

Principal Investigator

Matsuo Naoki  大阪大学, 医学系研究科, 准教授 (10508956)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords記憶 / マウス / 記憶学習
Outline of Final Research Achievements

By taking advantage of a transgenic system that we have previously developed, we generated transgenic mice expressing ChR2 or hM3Dq DREADD specifically in neurons that were activated during learning. By utilizing the transgenic mice, we artificially reactivated engram cells in the hippocampus and then examined the reactivation of engram cells in different brain areas.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 6 results)

  • [Journal Article] Organization of the claustrum-to-entorhinal cortical connection in mice2017

    • Author(s)
      Kitanishi T, Matsuo N
    • Journal Title

      J. Neurosci.

      Volume: 37 Issue: 2 Pages: 269-280

    • DOI

      10.1523/jneurosci.1360-16.2017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pharmacogenetic reactivation of the original engram evokes an extinguished fear memory2017

    • Author(s)
      Yoshii T, Hosokawa H, Matsuo N
    • Journal Title

      Neuropharmacology

      Volume: 113 Pages: 1-9

    • DOI

      10.1016/j.neuropharm.2016.09.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Loss of ensemble segregation in dentate gyrus, but not in somatosensory cortex, during contextual fear memory generalization.2016

    • Author(s)
      Yokoyama M, Matsuo N
    • Journal Title

      Front. Behav. Neurosci.

      Volume: 10 Pages: 218-218

    • DOI

      10.3389/fnbeh.2016.00218

    • NAID

      120005973400

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Observation and manipulation of memory engram2017

    • Author(s)
      Naoki Matsuo
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Visualization and manipulation of memory engram2016

    • Author(s)
      Naoki Matsuo
    • Organizer
      NIPS International Workshop
    • Place of Presentation
      岡崎市
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Visualization and manipulation of memory engram2016

    • Author(s)
      Naoki Matsuo
    • Organizer
      The 47th NIPS International Symposium
    • Place of Presentation
      岡崎市
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 実験動物としてマウスを用いた記憶学習の仕組みの研究2016

    • Author(s)
      松尾直毅
    • Organizer
      第131回関西実験動物研究会
    • Place of Presentation
      吹田市
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 記憶の汎化に伴う活動神経アンサンブルの変化2015

    • Author(s)
      松尾直毅
    • Organizer
      第45回日本精神神経薬理学会・第37回日本生物学的精神医学会 合同年会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Genetic manipulation of memory engram2015

    • Author(s)
      Naoki Matsuo
    • Organizer
      第58回日本神経化学会大会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2019-12-27  

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