Research Project
Grant-in-Aid for Challenging Exploratory Research
To measure electrical activity of the brain while a model animal is conducting cognitive-behavioral tasks is one of the most fundamental techniques for studying the brain function. To further understand how the neurons integrate synaptic inputs and generate action potentials, it is important to measure not only action potentials but also sub-threshold small potentials such as postsynaptic potentials. However, it is very difficult to measure sub-threshold potentials in a freely behaving animal, because the conventional electrophysiological devices for measuring sub-threshold potentials is very large and not suitable to the neural recording of behaving animals. In this study, we developed a small and light-weight electro-phsiological device which enables us to conduct intracellular recording to detect sub-threshold postsynaptic potentials.
All 2017 2016 2015 Other
All Journal Article (5 results) (of which Int'l Joint Research: 2 results, Peer Reviewed: 5 results, Open Access: 5 results, Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Int'l Joint Research: 3 results, Invited: 2 results) Remarks (1 results)
Proc. Natl. Acad. Sci. USA
Volume: 114 Issue: 3 Pages: 604-609
10.1073/pnas.1610787114
Cell Reports
Volume: 17 Issue: 9 Pages: 2405-2417
10.1016/j.celrep.2016.10.088
120005868496
Scientific Reports
Volume: 6 Issue: 1 Pages: 34904-34904
10.1038/srep34904
120005850272
Proc. Natl. Acad. Sci. U.S.A.
Volume: 112 Issue: 24 Pages: 7599-7604
10.1073/pnas.1413484112
120005672630
Neuroscience.
Volume: 308 Pages: 115-124
10.1016/j.neuroscience.2015.09.014
http://www.phy.med.kyoto-u.ac.jp/