Development of measuring neural activity in a freely behaving animal
Project/Area Number |
15K14315
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neurophysiology / General neuroscience
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Research Institution | Kyoto University |
Principal Investigator |
Watanabe Dai 京都大学, 医学研究科, 教授 (90303817)
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Co-Investigator(Renkei-kenkyūsha) |
Hamaguchi Kosuke 京都大学, 医学研究科, 講師 (50415270)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 電気生理学 / 細胞内記録 / 光学的計測 / 光遺伝学 |
Outline of Final Research Achievements |
To measure electrical activity of the brain while a model animal is conducting cognitive-behavioral tasks is one of the most fundamental techniques for studying the brain function. To further understand how the neurons integrate synaptic inputs and generate action potentials, it is important to measure not only action potentials but also sub-threshold small potentials such as postsynaptic potentials. However, it is very difficult to measure sub-threshold potentials in a freely behaving animal, because the conventional electrophysiological devices for measuring sub-threshold potentials is very large and not suitable to the neural recording of behaving animals. In this study, we developed a small and light-weight electro-phsiological device which enables us to conduct intracellular recording to detect sub-threshold postsynaptic potentials.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys.2017
Author(s)
Tohyama, T., Kinoshita, M., Kobayashi, K., Isa, K., Watanabe, D., Kobayashi, K., Liu, M., and Isa, T.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 114
Issue: 3
Pages: 604-609
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] mDia and ROCK mediate actin-dependent presynaptic remodeling regulating synaptic efficacy and anxiety.2016
Author(s)
Deguchi Y, Harada M, Shinohara R, Lazarus M, Cherasse Y, Urade Y, Yamada D, Sekiguchi M, Watanabe D, Furuyashiki T, Narumiya S.
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Journal Title
Cell Reports
Volume: 17
Issue: 9
Pages: 2405-2417
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons2016
Author(s)
Imamura, K., Sahara, N., Kanaan, N. M., Tsukita, K., Kondo, T., Kutoku, Y., Ohsawa, Y., Sunada, Y., Kawakami, K., Hotta, A., Yawata, S., Watanabe, D., Hasegawa, M., Trojanowski, J. Q., Lee, V. M.-Y., Suhara, T., Higuchi, M., and Inoue, H.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 34904-34904
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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