| Project/Area Number |
15K14320
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Tamagawa University |
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Principal Investigator |
Kimura Minoru 玉川大学, 脳科学研究所, 教授 (40118451)
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| Co-Investigator(Renkei-kenkyūsha) |
ENOMOTO Kazuki 玉川大学, 脳科学研究所, 特任助教 (10585904)
YAMANAKA Ko 順天堂大学, スポーツ健康科学部, 助教 (40551479)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | システム神経生理学 |
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| Outline of Final Research Achievements |
We recorded spike activity of optogenetically identified direct- and indirect-pathway neurons in the striatum when rats performed conditioning task. Direct pathway neurons were activated by reward outcome and inhibited by no-reward outcome of behavioral choice.
In contrast indirect-pathway neurons were activated by no-reward outcome and inhibited by reward outcome. The outcome coding was mostly associated with executed specific.
Direct- and indirect-pathway neurons signaled stay selection switch selection in subsequent trial. Optogenetical enhancement of responses of indirect-pathway neurons to no-reward outcome raised the probability of behavioral switch, whereas enhancement of responses of direct-pathway SPNs to reward outcome raised the probability to stay previous choice. Our results reveal that the direct- and indirect-pathways differentially signal positive and negative outcomes and promote subsequent behavioral selection to enable reward to be efficiently realized.
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