Optogenetical approach of striatal direct- and indirect-pathways for learning
Project/Area Number |
15K14320
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neurophysiology / General neuroscience
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Research Institution | Tamagawa University |
Principal Investigator |
Kimura Minoru 玉川大学, 脳科学研究所, 教授 (40118451)
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Co-Investigator(Renkei-kenkyūsha) |
ENOMOTO Kazuki 玉川大学, 脳科学研究所, 特任助教 (10585904)
YAMANAKA Ko 順天堂大学, スポーツ健康科学部, 助教 (40551479)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | システム神経生理学 |
Outline of Final Research Achievements |
We recorded spike activity of optogenetically identified direct- and indirect-pathway neurons in the striatum when rats performed conditioning task. Direct pathway neurons were activated by reward outcome and inhibited by no-reward outcome of behavioral choice. In contrast indirect-pathway neurons were activated by no-reward outcome and inhibited by reward outcome. The outcome coding was mostly associated with executed specific. Direct- and indirect-pathway neurons signaled stay selection switch selection in subsequent trial. Optogenetical enhancement of responses of indirect-pathway neurons to no-reward outcome raised the probability of behavioral switch, whereas enhancement of responses of direct-pathway SPNs to reward outcome raised the probability to stay previous choice. Our results reveal that the direct- and indirect-pathways differentially signal positive and negative outcomes and promote subsequent behavioral selection to enable reward to be efficiently realized.
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Report
(3 results)
Research Products
(8 results)
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[Presentation] Roles of the centromedian nucleus of thalamus and its projection to the striatum in cognitive and behavioral biases.2015
Author(s)
Kimura, M., Yamanaka, K., Minamimoto, T., Hori, Y. and Ueda, Y.
Organizer
Neuroscience 2015, SfN's 45th annual meeting
Place of Presentation
McCormic Place, Chicago, Illinois, USA
Year and Date
2015-10-21
Related Report
Int'l Joint Research
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