| Project/Area Number |
15K14328
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
CUI Yilong 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (60312229)
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| Co-Investigator(Kenkyū-buntansha) |
小林 真之 日本大学, 歯学部, 教授 (00300830)
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| Co-Investigator(Renkei-kenkyūsha) |
Okauchi Takashi 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, リサーチアソシエイト (80415405)
Shingaki Tomotaka 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 研究員 (60643187)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Placebo / Pain / Neuroimaging / PET / Opioid / プラセボ / 小動物脳機能画像解析 / オピオイド / 痛み / 心と脳 / ＰＥＴ |
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| Outline of Final Research Achievements |
Placebo analgesia is a kind of pain relief that follows the administration of an inert treatment and is thought to result from expectation and implication. However, the underlying neural and molecular mechanisms in detail are still poorly understood. To address this issue, we tried to establish an animal model of placebo analgesia in neuropathic pain rats using Pavlovian conditioning, in which neuropathic pain was caused by tight ligation of the lumber 5/6 spinal nerves and Pavlovian conditioning was established with a painkiller (gabapentin) as the unconditioned stimulus. We found that after a few trials of paired stimulation of gabapentin with conditioning stimulus, the inert treatment (saline, i.p.) alone also induced analgesia in some animals. Such placebo analgesia was completely blocked by naloxone, a mu-opioid receptor antagonist. Small-animal neuroimaging results also showed that regional brain activity in the mPFC, rACC, and vlPAG positive correlation with placebo score.
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