| Project/Area Number |
15K14334
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Fukuda Takaichi 熊本大学, 大学院生命科学研究部(医), 教授 (50253414)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIGEMATSU Naoki 熊本大学, 大学院生命科学研究部, 助教 (30469613)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 体性感覚野 / バレル / ギャップ結合 / GABA / パルブアルブミン / インターニューロン / gap junction / 電気シナプス / バレル野 / 体性感覚 / マウス / 免疫組織化学 |
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| Outline of Final Research Achievements |
Barrel area in rodents has well-ordered structure that facilitates investigation of the cerebral cortex, but I noticed further significance of the neighboring “mini-barrel region”, where processing of information from miniature vibrissae should occur with higher resolution, just as processing of retinal information from the fovea centralis. Thus I examined structural organization of parvabumin (PV)-positive interneurons in layer 4 of the mini-barrel region in mice and compared it with that in barrels. The analysis has shown that the density of PV neurons in mini-barrels is significantly higher than that in barrels, supporting the hypothesis of high-resolution regulatory mechanism in mini-barrels. Simultaneous analysis in barrels further revealed that PV neurons in layer 4 are categorized into 4 subtypes and that gap junctions interconnect different subtypes with connectivity unique to each subtype, indicating the presence of novel organized architecture for somatosensory processing.
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