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Analysis of the AUTS2 gene and its relationship with focal cortical dysplasia

Research Project

Project/Area Number 15K14337
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Nerve anatomy/Neuropathology
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Hoshino Mikio  国立研究開発法人国立精神・神経医療研究センター, 神経研究所 病態生化学研究部, 部長 (70301273)

Project Period (FY) 2015-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords神経科学 / 発生・分化 / 脳神経疾患 / 脳・神経 / 解剖学
Outline of Final Research Achievements

AUTS2 is related to various psychiatric disorders, but its function has been elusive. We have previously found that AUTS2 activates Rac1 and simultaneously downregulates Cdc42 to reorganize actin cytoskeleton and is involved in cortical neuronal migration and neuritogenesis.In this study, we further found that AUTS2 is also involved in synaptogenesis in the developing brain. Moreover, Auts2-deficient mice display behavioral abnormalities including anxiety-related emotion and memory formation. These findings suggest that AUTS2 acts as a novel regulator for Rho family GTPases contributing to brain development and give good insights into the pathology of human psychiatric disorders with AUTS2 mutations.

Report

(2 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (7 results)

All 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results)

  • [Journal Article] Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox92016

    • Author(s)
      Hashimoto R, Hori K, Owa T, Miyashita S, Dewa K, Masuyama N, Sakai K, Hayase Y, Seto Y, Inoue YU, Inoue T, Ichinohe N, Kawaguchi Y, Akiyama H, Koizumi S, Hoshino M
    • Journal Title

      Mech Dev

      Volume: 140 Pages: 25-40

    • DOI

      10.1016/j.mod.2016.02.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Heterozygous Disruption of Autism susceptibility candidate 2 Causes Impaired Emotional Control and Cognitive Memory.2015

    • Author(s)
      Hori K, Nagai T, Shan W, Sakamoto A, Abe M, Yamazaki M, Sakimura K, Yamada K, Hoshino M.
    • Journal Title

      PLoS One

      Volume: 30 Issue: 12 Pages: e0145979-e0145979

    • DOI

      10.1371/journal.pone.0145979

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Classic cadherin expressions balance postnatal neuronal positioning and dendrite dynamics to elaborate the specific cytoarchitecture of the mouse cortical area2015

    • Author(s)
      Egusa SF, Inoue YU, Asami J, Terakawa YW, Hoshino M, Inoue T
    • Journal Title

      Neurosci Res

      Volume: 105 Pages: 49-64

    • DOI

      10.1016/j.neures.2015.09.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cytoplasmic function of AUTS2 in neural network formation2015

    • Author(s)
      Hoshino M, Nagai T, Shen W, Sakamoto A, Taya S, Hashimoto R, Hayashi T, Abe M, Yamazaki M, Nakao K, Nishioka T, Sakimura K, Yamada K, Kaibuchi K, Hori K
    • Organizer
      Society for Neuroscience 45th annual meeting
    • Place of Presentation
      McCormick Place, Chicago, IL, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of autism susceptibility candidate 2 gene during development2015

    • Author(s)
      Hoshino M, Hori K
    • Organizer
      Tohoku Forum for Creativity, Frontiers of Brain Science, “Development and Disease” symposium
    • Place of Presentation
      Tohoku University, Sendai, Japan
    • Year and Date
      2015-08-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 各種精神疾患とAUTS2遺伝子、そしてヒトの進化2015

    • Author(s)
      星野幹雄
    • Organizer
      平成27年度生理学研究所研究会「シナプスの構造構築と機能発現の分子基盤」
    • Place of Presentation
      生理学研究所, 岡崎
    • Year and Date
      2015-06-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Physiological and pathological analyses of an autism-related gene2015

    • Author(s)
      Hoshino M
    • Organizer
      EMBO Workshop on Cortical Development in Health and Disease
    • Place of Presentation
      Weizmann Institute of Science, Rehovot, Israel
    • Year and Date
      2015-04-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2015-04-16   Modified: 2017-05-10  

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