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Study of biomarkers of Parkinson's disease by the amplification of amyloid fibrils in biological sample

Research Project

Project/Area Number 15K14339
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Nerve anatomy/Neuropathology
Research InstitutionOsaka University

Principal Investigator

Araki Katsuya  大阪大学, 医学部附属病院, 医員 (50649431)

Co-Investigator(Renkei-kenkyūsha) MOCHIZUKI Hideki  大阪大学, 大学院医学系研究科神経内科学, 教授 (90230044)
GOTO Yuji  大阪大学, 蛋白質研究所, 教授 (40153770)
YAGI Naoto  公益財団法人高輝度光科学研究センター(JASRI), 利用研究促進部門, 副部門長 (80133940)
Project Period (FY) 2015-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywordsパーキンソン病 / 医療診断装置 / アミロイド / レビー小体 / 神経内科学 / アミロイド線維
Outline of Final Research Achievements

Useful and simple diagnosis of Parkinson's disease does not yet exist. The definitive diagnosis is made by autopsy, the presence of Lewy bodies, which are characteristic of Parkinson's disease, is important. We have devised a method of detecting early changes that occur in connection with the formation of Lewy bodies in Parkinson's disease patient’s cerebrospinal fluid. In the present study, since we showed the result that our method could diagnose the Parkinson's disease, we aim to put the method into practical use in 5 to 10 years.

Report

(2 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (4 results)

All 2016 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Synchrotron FTIR Micro-Spectroscopy for Structural Analysis of Lewy Bodies in the Brain of Parkinson’s Disease Patients2015

    • Author(s)
      K. Araki, N. Yagi, Y. Ikemoto, S. Choong, H. Hayakawa, G. Beck, H. Sumi, H. Fujimura, T. Moriwaki, Y. Nagai, Y. Goto and H. Mochizuki
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 17625-17625

    • DOI

      10.1038/srep17625

    • NAID

      120006557628

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] The structure analysis for alpha-synuclein and Lewy bodies of Parkinson's disease patients with synchrotron radiation2016

    • Author(s)
      Katsuya Araki, Naoto Yagi, Rie Nakatani, Hideki Hayakawa, Kosuke Baba, Hideki Mochizuki,
    • Organizer
      5th AOPMC
    • Place of Presentation
      マニラ(フィリピン)
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson’s disease patients2015

    • Author(s)
      Katsuya Araki
    • Organizer
      Basic Scientists Summer School
    • Place of Presentation
      秋葉原コンベンションホール
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structure analysis of post-translationally modified alpha-synuclein by small angle X-ray scattering (SAXS)2015

    • Author(s)
      Katsuya Araki, Naoto Yagi, Rie Nakatani, Hisashi Yagi, Yuji Goto, Hideki Mochizuki
    • Organizer
      第56回 神経学会総会
    • Place of Presentation
      新潟コンベンションセンター
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2017-05-10  

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