| Project/Area Number |
15K14342
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
Ito Masafumi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (80393114)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAKAMI Kyojiro 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究員 (90589227)
FUJITA Yasunori 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究員 (30515888)
TANAKA Masashi 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 協力研究員 (60155166)
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| Research Collaborator |
FUJISAKI Kento
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | エクソソーム / 認知症 / アルツハイマー病 |
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| Outline of Final Research Achievements |
Exosomes that are secreted from cells reflect the molecular signature of cells from which they are derived. Therefore, exosomes are considered to be a novel type of biomarker as well as tool for intercellular communication. In the present study, we first improved the isolation method of exosomes from mouse frozen brain tissues. Then, we found that (1) exosomes can be isolated from human brain tissues, (2) brain exosomes consist of those derived from neuron and glial cells, and (3) brain exosomes isolated from the brain of Alzheimer’s disease patients contain amyloid beta, providing the basis for exosome research in human brain.
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