The role of brain exosomes in cognitive diseases
Project/Area Number |
15K14342
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
Principal Investigator |
Ito Masafumi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (80393114)
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Co-Investigator(Renkei-kenkyūsha) |
KAWAKAMI Kyojiro 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究員 (90589227)
FUJITA Yasunori 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究員 (30515888)
TANAKA Masashi 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 協力研究員 (60155166)
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Research Collaborator |
FUJISAKI Kento
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | エクソソーム / 認知症 / アルツハイマー病 |
Outline of Final Research Achievements |
Exosomes that are secreted from cells reflect the molecular signature of cells from which they are derived. Therefore, exosomes are considered to be a novel type of biomarker as well as tool for intercellular communication. In the present study, we first improved the isolation method of exosomes from mouse frozen brain tissues. Then, we found that (1) exosomes can be isolated from human brain tissues, (2) brain exosomes consist of those derived from neuron and glial cells, and (3) brain exosomes isolated from the brain of Alzheimer’s disease patients contain amyloid beta, providing the basis for exosome research in human brain.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Gamma-glutamyltransferase activity in exosomes as a potential marker for prostate cancer2017
Author(s)
Kawakami K, Fujita Y, Matsuda Y, Arai T, Horie K, Kameyama K, Kato T, Masunaga K, Kasuya Y, Tanaka M, Mizutani K, Deguchi T, Ito M
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Journal Title
Related Report
Peer Reviewed / Open Access
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[Presentation] エクソソーム上γ-グルタミルトランスフェラーゼ活性の前立腺がんと前立腺肥大の鑑別における有用性2016
Author(s)
川上恭司郎, 藤田泰典, 松田陽子, 新井冨生, 堀江憲吾, 亀山紘司, 加藤卓, 桝永浩一, 粕谷豊, 田中雅嗣, 水谷晃輔, 出口隆, 伊藤雅史
Organizer
第39回日本分子生物学会年会
Place of Presentation
パシフィコ横浜、横浜
Year and Date
2016-11-30
Related Report
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[Presentation] Exosomal gamma-glutamyltransferase activity as a marker for prostate cancer2016
Author(s)
Ito M, Kawakami K, Fujita Y, Matsuda Y, Arai T, Horie K, Kameyama K, Kato T, Masunaga K, Kasuya Y, Tanaka M, Deguchi T, Mizutani K
Organizer
2016 ASEMV annual meeting
Place of Presentation
Asilomar Conference Center, Monterey, USA
Year and Date
2016-10-20
Related Report
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