Occurrence of anxiety through a specific neuronal group in the bed nucleus of stria terminlis

• Project/Area Number: 15K14345
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Nagoya University (2016); The University of Tokyo (2015)
• Principal Investigator: Takemoto Sayaka 名古屋大学, 環境医学研究所, 教授 (70372365)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 分界条床核 / カルシウム依存的リン酸化酵素 / 扁桃体中心核 / 情動 / 局所回路 / 恐怖記憶 / 脳神経科学 / 不安

Outline of Final Research Achievements

The occurrence of anxiety is modified by environment. One of the subcortical nucleus related to anxiety regulation is the bed nucleus of stria terminalis and the central nucleus of amygdala, which are included in the extended amygdala. In this study we focused on specific groups of neurons in these regions. We performed anatomical study to reveal connections between two regions. Furthermore, we established methods measuring and manipulating the neuronal groups in this area to understand the pathophysiology of anxiety disorders.

Research Products

• [Journal Article] Calmodulin kinases: essential regulators in health and disease. (2017)
  • Author(s): Takemoto-Kimura S, Suzuki K, Horigane SI, Kamijo S, Inoue M, Sakamoto M, Fujii H, Bito H.
  • Journal Title: J Neurochem. Volume: - Issue: 6 Pages: 808-818
  • DOI: 10.1111/jnc.14020
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIα pathway during neuronal polarization. (2016)
  • Author(s): Horigane S, Ageta-Ishihara N, Kamijo S, Fujii H, Okamura M, Kinoshita M, Takemoto-Kimura S, Bito H
  • Journal Title: Mol Brain. Volume: 9 Issue: 1 Pages: 8-8
  • DOI: 10.1186/s13041-016-0189-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 神経細胞形態制御を担うカルシウム依存性リン酸化経路の神経機能解明 (2016)
  • Author(s): 竹本（木村）さやか、堀金慎一郎、鈴木敢三、児山博亮、金亮、上條諭志、藤井哉、尾藤晴彦
  • Organizer: 第121回日本解剖学会総会
  • Place of Presentation: ビックサイト福島
  • Year and Date: 2016-03-28
  • Invited
• [Presentation] 扁桃体神経回路におけるカルシウム依存的リン酸化経路と情動行動 (2016)
  • Author(s): 竹本さやか、遠藤俊裕、金亮、鈴木敢三、藤井哉、尾藤晴彦
  • Organizer: 第46回日本神経精神薬理学会
  • Invited
• [Presentation] Calcium-dependent phosphorylation signaling in emotional and social limbic circuit (2016)
  • Author(s): Takemoto-Kimura S, Suzuki K, Endo T, Kim R, Koyama H, Horigane S, Fujii H, Bito H
  • Organizer: 第39回日本神経科学大会
  • Invited
• [Presentation] Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIa pathway (2016)
  • Author(s): Horigane S, Ageta-Ishihara N, Kamijyo S, Fujii H, Okamura M, Kinoshita M, Takemoto-Kimura S, Bito H
  • Organizer: 第39回日本神経科学大会
• [Presentation] Excitation-morphogenesis coupling during corticogenesis: a critical role for L-type voltage-gated calcium channel-driven spontaneous calcium elevations in neurite extension and radial migration (2016)
  • Author(s): Kamijo S, Suzuki K, Horigane S-I, Takemoto-Kimura S, Bito H
  • Organizer: The 46th Annual Meeting of the Society for Neuroscience
• [Presentation] Mapping emerging neocortical active ensembles during retrieval of remote memory via functional bioluminescence imaging of Arc promoter activity (2016)
  • Author(s): Yagishita-Kyo N, Okuno H, Kamijo S, Kawashima T, Uemura Y, Takemoto-Kimura S, Bito H
  • Organizer: The 46th Annual Meeting of the Society for Neuroscience
• [Presentation] 高感度、超高速赤色カルシウムインディケーターの合理的設計による開発 (2015)
  • Author(s): 井上昌俊, 竹内敦也, 堀金慎一郎, 大倉正道, 安藤恵子, 藤井哉, 上條諭志, 竹本-木村 さやか, 狩野方伸, 中井淳一, 喜多村和郎, 尾藤晴彦
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場・神戸国際展示場
  • Year and Date: 2015-07-28
  • Invited
• [Presentation] 樹状突起形成および情動行動におけるカルシウム依存的リン酸化経路の新規機能解明 (2015)
  • Author(s): 竹本ー木村さやか, 鈴木敢三, 上條諭志, 金 亮, 堀金慎一郎, 尾藤晴彦
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場・神戸国際展示場
  • Year and Date: 2015-07-28
  • Invited