| Project/Area Number |
15K14350
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
SUGO Noriyuki 大阪大学, 生命機能研究科, 助教 (20372625)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経細胞 / DNA損傷 / エピジェネティクス / 転写 / １分子イメージング / 分子・細胞・神経生物学 / DNA修復 |
|---|
| Outline of Final Research Achievements |
DNA repair is an important mechanism in neuronal differentiation, in addition to transcription and chromatin regulation. Here, we examined DNA repair dynamics during neuronal differentiation using single-molecule imaging technique. We revealed the dynamics of DNA polymerase β, one of DNA repair enzymes, in the nucleus of cortical neurons.
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