Involvement of microglial cells in the sleep/wake cycle
Project/Area Number |
15K14351
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Ehime University |
Principal Investigator |
Tanaka Junya 愛媛大学, 医学系研究科, 教授 (70217040)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | microglia / circadian / sleep / synapse / noradrenaline / EEG / phagocytosis / eat-me signal / マイクログリア / シナプス / 貪食 / 睡眠覚醒リズム / 入眠覚醒リズム / グルタミン酸 / ノルアドレナリン |
Outline of Final Research Achievements |
① Microglial cells become activated during sleeping time (light period; Zeitgeber Time (ZT0-12), while actively phagocytizing synapses. Around the waking time (dark period; ZT12-24), microglial phagocytic activity is suppressed. Consequently, amounts of synapses reduced during the light period as revealed by Western blotting.② Circadian changes in the concentration of noradrenaline caused the changes in the activity of microglial cells. Higher concentration of noradrenaline was correlated with suppressed microglial activity.③ It is likely that elimination of synapses by microglial cells causes asleep and maintain the sleep.④ Microglial cells eliminate only synapses with immunoreactivity of C3 or MFG-E8, suggesting the involvement of microglial cells during asleep in memory consolidation.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] The hypnotic bromovalerylurea ameliorates 6-hydroxydopamine-induced dopaminergic neuron loss while suppressing expression of interferon regulatory factors by microglia2016
Author(s)
Hiromi Higaki, Mohammed Emamussalehin Choudhury, Chisato Kawamoto, Keisuke Miyamoto, Afsana Islam, Yurika Ishii, Kazuya Miyanishi, Haruna Takeda, Naoto Seo, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano and Junya Tanaka
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Journal Title
Neurochemistry International
Volume: 99
Pages: 158-168
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A Truncated form of CD200 (CD200S) Expressed on Glioma Cells Prolonged Survival in a Rat Glioma Model by Induction of a Dendritic Cell-Like Phenotype in Tumor-Associated Macrophages2016
Author(s)
Kana Kobayashi, Hajime Yano, Akihiro Umakoshi, Shirabe Matsumoto, Ayano Mise, Yu Funahashi, Yoshitomo Ueno, Yoshiaki Kamei, Yasutsugu Takada, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanaka
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Journal Title
Neoplasia
Volume: 18
Issue: 4
Pages: 229-241
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na+/H+ exchanger 1 expression2016
Author(s)
Ryutaro Nishioka, Kana Sugimoto, Hitomi Aono, Ayano Mise, Mohammed E. Choudhury, Kazuya Miyanishi, Afsana Islam, Takahiro Fujita, Haruna Takeda, Hisaaki Takahashi, Hajime Yano, Junya Tanaka
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Journal Title
Experimental Neurology
Volume: 277
Pages: 150-161
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Ameliorative Effects of a Hypnotic Bromvalerylurea in Sepsis2015
Author(s)
Kikuchi S, Nishihara T, Kawasaki S, Abe N, Kuwabara J, Choudhury ME, Takahashi H, Yano H, Nagaro T, Watanabe Y, Aibiki M, Tanaka J
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Journal Title
Biochem Biophys Res Commun.
Volume: 459
Issue: 2
Pages: 319-326
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] miR340 Suppresses the Stem-like Cell Function of Glioma-Initiating Cells by Targeting Tissue Plasminogen Activator2015
Author(s)
Daisuke Yamashita, Toru Kondo, Shiro Ohue, Hisaaki Takahashi, Madoka Ishikawa, Ryo Matoba, Satoshi Suehiro, Shohei Kohno, Hironobu Harada, Junya Tanaka, Takanori Ohnishi
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Journal Title
Cancer Research
Volume: 75
Issue: 6
Pages: 1123-1133
DOI
Related Report
Peer Reviewed
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[Journal Article] CD200+ and CD 200- macrophages accumulated in ischemic lesions of rat brain: The two populations cannot be classified as either M1 or M2 macrophages2015
Author(s)
Shirabe Matsumoto, Junya Tanaka, Hajime Yano, Hisaaki Takahashi, Kana Sugimoto, Shiro Ohue, Akihiro Inoue, Hitomi Aono, Akari Kusakawa, Hideaki Watanabe, Yoshiaki Kumon, Takanori Ohnishi
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Journal Title
Journal of Neuroimmunology
Volume: 282
Pages: 7-20
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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