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Multifaceted pain research in nonhuman primates

Research Project

Project/Area Number 15K14364
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Laboratory animal science
Research InstitutionKyoto University

Principal Investigator

Miyabe Takako  京都大学, 霊長類研究所, 助教 (10437288)

Research Collaborator MILLS Daniel  
MUTA Kanako  
NISHIMURA Ryohei  
OKANO J Hirotaka  
OHOTA Hiroki  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords痛み / 非ヒト霊長類 / 行動 / 表情 / 疼痛管理 / 疼痛評価 / サル / FACS / マーモセット / fMRI / チンパンジー / 実験動物学 / 動物行動学 / 霊長類学 / 実験動物福祉
Outline of Final Research Achievements

The objectives of this study was to evaluate pain in nonhuman primates using facial expression and behavior. Injured Japanese macaques by natural causes, and Japanese macaques and common marmosets that went through surgeries such as laparotomy for other research purposes were video recorded before or during the painful situations. As a multi institutional collaborative study, facial expressions and behavior were evaluated using computer software. In addition, questionnaire surveys for primate veterinarians were conducted. The aim of the surveys were 1) to investigate current knowledge and attitudes of veterinarians who work with nonhuman on acute pain and assess the effect of demographics including gender and years of experience and 2) to share the knowledge on clinical signs of acute pain in macaques to create better pain assessment tools.

Academic Significance and Societal Importance of the Research Achievements

サル類は、ヒトに近い実験動物として様々な医学、生命科学研究に使用されている。人道的配慮として苦痛軽減が必須であるが、痛みを評価するのは難しい。本研究により、ニホンザルにおける痛みに関連する表情は口元の緊張や目元に表れることが示唆された。さらなる検証が必要であるが、他の行動指標と合わせて表情にも注目することで、より良い疼痛管理が可能となることが期待できる。また、サル類を扱う獣医師を対象としたアンケート調査により、痛みに関する意識、関心は高いと考えられ、痛みの指標となる行動や表情のリストを作成することができた。本研究の成果をもとに、さらなる研究を発展させ、動物福祉に配慮した社会の推進に貢献したい。

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] University of Lincoln(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Lincoln/The University of Nottingham(United Kingdom)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] University of Lincoln(United Kingdom)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Hepatocellular carcinoma with intracranial metastasis in a Japanese macaque (Macaca fuscata)2017

    • Author(s)
      Takako Miyabe-Nishiwaki, Akihiro Hirata, Akihisa Kaneko, Akiyo Ishigami, Yoko Miyamoto, Atsushi Yamanaka, Keishi Owaki, Hiroki Sakai, Tokuma Yanai and Juri Suzuki
    • Journal Title

      Journal of Medical Primatology

      Volume: 印刷中 Issue: 3 Pages: 93-100

    • DOI

      10.1111/jmp.12261

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] コモンマーモセットにおける急性疼痛評価法の確立2017

    • Author(s)
      牟田佳那子、宮部貴子、太田裕貴、岡野ジェイムス洋尚、Lauren Finka, Daniel Mills、西村亮平
    • Organizer
      第7回日本マーモセット研究会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] コモンマーモセットにおけるプロポフォールの薬物動態解析2016

    • Author(s)
      牟田佳奈子、宮部貴子、増井健一、矢島功、飯塚智也、兼子明久、西村亮平
    • Organizer
      第6回日本マーモセット研究会
    • Place of Presentation
      東京大学農学部弥生講堂
    • Year and Date
      2016-12-12
    • Related Report
      2016 Research-status Report
  • [Presentation] マーモセットにおけるアルファキサロン―ケタミン、アルファキサロン―メデトミジンーブトルファノールの麻酔効果2016

    • Author(s)
      宮部貴子、三輪美樹、鴻池菜保、兼子明久、石上暁代、 夏目尊好、中村克樹
    • Organizer
      第5回日本マーモセット研究会大会
    • Place of Presentation
      東京
    • Year and Date
      2016-01-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Hypnotic effects and pharmacokinetics of a single bolus dose of alfaxalone in Japanese macaques (Macaca fuscata)2015

    • Author(s)
      T. Miyabe-Nishiwaki, A. Kaneko, N. Suda-Hashimoto, Y. Indo, A. Ishigami, S. Aisu, A. Yamanaka, K. Nakamura, H. Akari, M. Okamoto, T. Fukui, K. Masui
    • Organizer
      12th World Congress of Veterinary Anaesthesiology
    • Place of Presentation
      京都
    • Year and Date
      2015-09-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2022-11-04  

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