Role of p53-inducible glutamine regulator GLS2 in the pathogenesis of NASH-HCC
| Project/Area Number |
15K14375
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Chiba University |
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Principal Investigator |
TANAKA Tomoaki 千葉大学, 大学院医学研究院, 教授 (50447299)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | NASH / 生活習慣病 / 肝臓がん / グルタミン代謝 / がん抑制遺伝子 / 肥満 / 癌抑制遺伝子 / 肝細胞癌 |
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| Outline of Final Research Achievements |
Recent epidemiologic evidence suggests that type 2 diabetes and obesity are at significantly higher risk for many types of cancer. In this context, p53 has been shown to control mitochondrial functions through regulation of ROS and cell metabolism, implicating its potential role in biologic links between diabetes and cancer. Here we have explored p53 targets to regulate cell metabolism using ChIP- and RNA-sequencing and identified GLS2, a key enzyme to convert glutamine to glutamate, thereby a regulator of glutathione synthesis and ATP production via TCA cycle. GLS2 overexpression inhibited cancer cell growth as well as invasion in both vitro and vivo, suggesting its potential role for tumor suppression. Thus, p53-GLS2 pathway may contribute to the common pathogenesis between life-style related diseases and cancer.
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6.2017
Author(s)
Yoshida A, Kitajima S, Li F, Cheng C, Takegami Y, Hayashi N, Nishimoto Y, Nagatani N, Kohno S, Muranaka S, Nishiuchi T, Suzuki S, Nakao S, Tanaka T, Hirose O, and Takahashi C.
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Journal Title
Oncotarget.
Volume: 8
Pages: 13872-13885
NAID
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Anti-FIRs (PUF60) auto-antibodies are detected in the sera of early-stage colon cancer patients.2016
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Kobayashi S, Hoshino T, Hiwasa T, Satoh M, Rahmutulla B, Tsuchida S, Komukai Y, Tanaka T, Matsubara H, Shimada H, Nomura F, Matsushita K.
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Journal Title
Oncotarget.
Volume: 7
Pages: 82493-82503
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cushing syndrome due to ACTH-secreting pheochromocytoma aggravated by a glucocorticoid-driven positive-feedback loop.2016
Author(s)
Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T
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Journal Title
J Clin Endocrinol Metab.
Volume: 101
Pages: 841-846
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical predictors of prolonged postresection hypotension after laparoscopic adrenalectomy for pheochromocytoma.2016
Author(s)
Namekawa T, Utsumi T, Kawamura K, Kamiya N, Imamoto T, Takiguchi T, Hashimoto N, Tanaka T, Naya Y, Suzuki H, Ichikawa T.
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Journal Title
Surgery
Volume: 159(3)
Issue: 3
Pages: 763-770
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] GERMLINE DELETION OF ARMC5 IN FAMILIAL PRIMARY MACRONODULAR ADRENAL HYPERPLASIA.2015
Author(s)
Suzuki S, Tatsuno I, Oohara E, Nakayama A, Komai E, Shiga A, Kono T, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Mayama T, Koide H, Sasano H, Nakatani Y, Imamoto T, Ichikawa T, Yokote K, Tanaka T.
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Journal Title
Endocr Pract.
Volume: 21
Issue: 10
Pages: 1152-60
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.2015
Author(s)
Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T.
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Journal Title
J Clin Endocrinol Metab.
Volume: 101(3)
Issue: 3
Pages: 841-846
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Risk of New-Onset Dyslipidemia After Laparoscopic Adrenalectomy in Patients with Primary Aldosteronism.2015
Author(s)
Kaga M, Utsumi T, Tanaka T, Kono T, Nagano H, Kawamura K, Kamiya N, Imamoto T, Nihei N, Naya Y, Suzuki H, Ichikawa T.
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Journal Title
World J Surg.
Volume: 39(12)
Issue: 12
Pages: 2935-2940
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet.2015
Author(s)
Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T.
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Journal Title
Sci Rep
Volume: 30
Issue: 1
Pages: 17565-17565
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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