Research Project
Grant-in-Aid for Challenging Exploratory Research
Recent epidemiologic evidence suggests that type 2 diabetes and obesity are at significantly higher risk for many types of cancer. In this context, p53 has been shown to control mitochondrial functions through regulation of ROS and cell metabolism, implicating its potential role in biologic links between diabetes and cancer. Here we have explored p53 targets to regulate cell metabolism using ChIP- and RNA-sequencing and identified GLS2, a key enzyme to convert glutamine to glutamate, thereby a regulator of glutathione synthesis and ATP production via TCA cycle. GLS2 overexpression inhibited cancer cell growth as well as invasion in both vitro and vivo, suggesting its potential role for tumor suppression. Thus, p53-GLS2 pathway may contribute to the common pathogenesis between life-style related diseases and cancer.
All 2017 2016 2015 Other
All Int'l Joint Research (3 results) Journal Article (10 results) (of which Int'l Joint Research: 3 results, Peer Reviewed: 10 results, Open Access: 10 results, Acknowledgement Compliant: 1 results) Presentation (31 results) Book (1 results)
J. Hum. Genet.
Volume: 62 Issue: 2 Pages: 141-150
10.1038/jhg.2016.150
40021064716
Oncotarget.
Volume: 8 Pages: 13872-13885
120006226780
Volume: 7 Pages: 82493-82503
J Clin Endocrinol Metab.
Volume: 101 Pages: 841-846
Nat Commun.
Volume: - Issue: 1 Pages: 11289-11289
10.1038/ncomms11289
Surgery
Volume: 159(3) Issue: 3 Pages: 763-770
10.1016/j.surg.2015.09.016
Endocr Pract.
Volume: 21 Issue: 10 Pages: 1152-60
10.4158/ep15756.or
Volume: 101(3) Issue: 3 Pages: 841-846
10.1210/jc.2015-2855
World J Surg.
Volume: 39(12) Issue: 12 Pages: 2935-2940
10.1007/s00268-015-3197-z
Sci Rep
Volume: 30 Issue: 1 Pages: 17565-17565
10.1038/srep17565
