Regulation of asymmetric cell division by the machinery maintaining genome stability
Project/Area Number |
15K14376
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
|
Research Institution | The University of Tokyo |
Principal Investigator |
MIYAGAWA KIYOSHI 東京大学, 大学院医学系研究科(医学部), 教授 (40200133)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 細胞周期 / 不均等細胞分裂 |
Outline of Final Research Achievements |
To clarify the molecular mechanism underlying the nature of cancer stem cells characterized by tolerance to cancer treatment, we tried to identify the machinery regulating both the DNA double-strand break response and asymmetric cell division. We found that Rad54B, which repairs double-strand breaks by homologous recombination and regulates cell-cycle checkpoint by degrading p53, promotes asymmetric cell division in the neuroblastoma-derived cell line. Furthermore, we found that Rad54B activates the Notch-signaling pathway by inhibiting Numb, which may be involved in asymmetric cell division.
|
Report
(3 results)
Research Products
(6 results)
-
[Journal Article] Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein.2016
Author(s)
Hashimoto T, Horikawa DD, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T, Enomoto A, Kondo K, Tanaka S, Hara Y, Koshikawa S, Sagara H, Miura T, Yokobori S, Miyagawa K, Suzuki Y, Kubo T, Oyama M, Kohara Y, Fujiyama A, Arakawa K, Katayama T, Toyoda A and Kunieda T
-
Journal Title
Nature Communications
Volume: 7
Issue: 1
Pages: 12808-12808
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
[Journal Article] High RAD54B expression: an independent predictor of postoperative distant recurrence in colorectal cancer patients.2015
Author(s)
Nagai Y, Yamamoto Y, Yasuhara T, Hata K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Nozawa H, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Yamanaka T, Miyagawa K, Watanabe T.
-
Journal Title
Oncotarget
Volume: 6
Issue: 25
Pages: 21064-21073
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-