Molecular basis for the establishment of early metastatic lesion through cell adaptation
Project/Area Number |
15K14381
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
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Research Institution | Kobe University |
Principal Investigator |
Shimono Yohei 神戸大学, 医学研究科, 准教授 (90594630)
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Research Collaborator |
MINAMI Hironobu 神戸大学, 大学院医学研究科, 教授
TAKAO Shintaro 神戸大学, 大学院医学研究科, 教授
CLARKE Michael スタンフォード大学, 幹細胞医学研究所, 教授
ISOBE Taichi スタンフォード大学, 幹細胞医学研究所, 博士研究員
MUKOHYAMA Junko 神戸大学, 大学院医学研究科, 大学院生
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 乳がん / 肝転移 / 異種移植マウス / マイクロRNA / エクソソーム |
Outline of Final Research Achievements |
Successful engraftment of disseminated metastatic cancer cells will require an adaptation of cancer cells to the specific microenvironments of metastasized organs. We identified the profile of microRNAs and genes specifically expressed in the early metastatic cancer cells directly isolated from the metastatic organ of human breast cancer patient-derived xenograft mice. We then analyzed the regulatory mechanism for the expression of miR-106b-25 cluster miRNAs. We also established the in vitro culture system in which primary liver cells and human breast cancer patient-derived xenograft cells were co-cultured to facilitate analyses of the adaptation of breast cancer cells to metastasized organs.
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Report
(3 results)
Research Products
(38 results)
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[Journal Article] Glucose metabolism targeting therapy and withaferin A are effective for EGFR-TKI induced drug tolerant persisters.2017
Author(s)
Kunimasa K, Nagano T, Shimono Y, Dokuni R, Kiriu T, Tokunaga S, Tamura D, Yamamoto M, Tachihara M, Kobayashi K, Satouchi M, Nishimura Y.
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Journal Title
Cancer Science
Volume: 印刷中
Issue: 7
Pages: 1368-1377
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells2017
Author(s)
Tominaga K, Shimamura T, Kimura N, Murayama T, Matsubara D, Kanauchi H, Niida A, Shimizu S, Nishioka K, Tsuji EI, Yano M, Sugano S, Shimono Y, Ishii H, Saya H, Mori M, Akashi K, Tada KI, Ogawa T, Tojo A, Miyano S, Gotoh N
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Journal Title
Oncogene
Volume: 36(9)
Issue: 9
Pages: 1276-1286
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer2015
Author(s)
Imamura Y, Mukohara T, Shimono Y, Funakoshi Y, Chayahara N, Toyoda M, Kiyota N, Takao S, Kono S, Nakatsura T, Minami H
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Journal Title
Oncol Rep
Volume: 33
Issue: 4
Pages: 1837-1843
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Downregulation of CXCR4 in Metastasized Breast Cancer Cells and Implication in Their Dormancy2015
Author(s)
Nobutani K, Shimono Y, Mizutani K, Ueda Y, Suzuki T, Kitayama M, Minami A, Momose K, Miyawaki K, Akashi K, Azuma T, Takai Y
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Journal Title
PLoS One
Volume: 10
Issue: 6
Pages: e0130032-e0130032
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Role of Hippo pathway in vivo2017
Author(s)
Miki Suzuki, Tomohiko Maehama, Hideru Togashi, Yohei Shimono, Akira Suzuki
Organizer
神戸大学・ワシントン大学・オスロ大学国際合同シンポジウム
Place of Presentation
神戸
Year and Date
2017-03-13
Related Report
Invited
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[Presentation] Downregulation of CXCR4 in metastasized breast cancer cells and implication in their dormancy2015
Author(s)
Yuki Ueda, Kentaro Nobutani, Yohei Shimono, Kiyohito Mizutani*, Toshihiro Suzuki*, Midori Kitayama*, Akihiro Minami, Kenji Momose, Kohta Miyawaki, Koichi Akashi, Takeshi Azuma, Yoshimi Takai
Organizer
第74回日本癌学会学術総会
Place of Presentation
名古屋
Year and Date
2015-10-08
Related Report
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