| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In general, reactive oxygen species (ROS) inhibit proliferation of non-tumor cells. Recently we found that high levels of ROS function to promote proliferation of colon cancer stem cells in vitro. We aimed to elucidate the molecular mechanism by which ROS differentially affect cell proliferation during carcinogenesis. In order to investigate the regulation of ROS levels during colon carcinogenesis, we established the in vitro three-dimensional culture from non-tumor and tumor tissues, and examined the gene expression profiles as well as ROS levels. We revealed that levels of NADPH oxidase increased during the carcinogenesis. Detailed investigation based on these observation is underway.
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