Regulation epithelial stem cells by reactive oxgens species during oncogenic transformation
Project/Area Number |
15K14390
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
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Research Institution | National Cancer Center Japan |
Principal Investigator |
Okamoto Koji 国立研究開発法人国立がん研究センター, 研究所, 分野長 (80342913)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 癌 / 幹細胞 |
Outline of Final Research Achievements |
In general, reactive oxygen species (ROS) inhibit proliferation of non-tumor cells. Recently we found that high levels of ROS function to promote proliferation of colon cancer stem cells in vitro. We aimed to elucidate the molecular mechanism by which ROS differentially affect cell proliferation during carcinogenesis. In order to investigate the regulation of ROS levels during colon carcinogenesis, we established the in vitro three-dimensional culture from non-tumor and tumor tissues, and examined the gene expression profiles as well as ROS levels. We revealed that levels of NADPH oxidase increased during the carcinogenesis. Detailed investigation based on these observation is underway.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer.2017
Author(s)
Yamawaki K, Ishiguro T, Mori Y, Yoshihara K, Suda K, Tamura R, Yamaguchi M, Sekine M, Kashima K, Higuchi M, Fujii M, Okamoto K, Enomoto T
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Journal Title
Cancer Sci.
Volume: 108
Issue: 4
Pages: 632-640
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] TNIK inhibition abrogates colorectal cancer stemness.2016
Author(s)
Masuda M, Uno Y, Ohbayashi N, Ohata H, Mimata A, Kukimoto-Niino M, Moriyama H, Kashimoto S, Inoue T, Goto N, Okamoto K, Shirouzu M, Sawa M, Yamada T.
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Journal Title
Nature Comm.
Volume: -
Issue: 1
Pages: 12586-12586
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Establishment and characterization of an in vitro model of ovarian cancer stem-like cells with an enhanced proliferative capacity.2016
Author(s)
Ishiguro T, Sato A, Ohata H, Ikarashi Y, Takahashi R, Ochiya T, Yoshida M, Tsuda H, Onda T, Kato T, Kasamatsu T, Enomoto T, Tanaka K, Nakagama H, Okamoto K.
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Journal Title
Cancer Research
Volume: 76
Issue: 1
Pages: 150-160
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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