| Project/Area Number |
15K14392
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
Kojima Yasushi 愛知県がんセンター(研究所), 分子病態学部, 主任研究員 (30464217)
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| Co-Investigator(Kenkyū-buntansha) |
ORIM FLORENCE 愛知県がんセンター(研究所), 分子病態学部, リサーチレジデント (90750810)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 大腸がん / 実験動物 |
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| Outline of Final Research Achievements |
Genetically engineered mouse models (GEMMs) are widely used to elucidate colon cancer development. However, these murine models have a serious drawback: they develop tumors mainly in the small intestine, and the tumor incidence in the large intestine is very low and poorly reproducible. Here we tried to generate a new GEMM that develop tumors in the colon exclusively and reproducibly. Data analysis of DNA microarrays and real-time PCR suggest that Aqp4 is highly expressed in the colon stem cell compartment. We have started to create a transgenic mouse with tamoxifen-inducible Cre recombinase expression driven by the Aqp4 gene promoter activity.
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