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Analysis of the effects of the host environment factors on pancreatic cancer malignancy at whole body levels

Research Project

Project/Area Number 15K14393
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionNational Cancer Center Japan

Principal Investigator

Takahashi Mami  国立研究開発法人国立がん研究センター, 研究所, ユニット長 (90214973)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords膵臓がん / 動物モデル / 宿主環境要因 / 悪性化
Outline of Final Research Achievements

Five culture cell lines which develop well/moderately differentiated carcinoma grafts in C57BL/6J mice were established from pancreatic tumors of Ptfla(Cre/+)/LSL-K-ras(G12D/+) mice. When these cell lines were subcutaneously implanted to obese Ay mice, promotion of tumor growth was observed in 2 cell lines. Orthotopic implantation of the cells develop pancreatic tumor grafts in which marked fatty infiltration was observed, and dissemination to visceral fat. This orthotopic allograft model is useful to study the effects of pancreatic cancer risk factors such as obesity/diabetes on pancreatic tumor growth at whole body levels.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2018 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Activated ductal proliferation induced by N-nitrosobis(2-oxopropyl)amine in fat-induced pancreas of KK-Ay mice.2018

    • Author(s)
      Hori, M., Mutoh, M., Ishigamori, R., Imai, T., Takahashi, M.
    • Journal Title

      In Vivo

      Volume: 32 Issue: 3 Pages: 499-505

    • DOI

      10.21873/invivo.11267

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Analysis of cancer promotion mechanisms using allograft models of mouse pancreatic adenocarcinoma cell lines2016

    • Author(s)
      高橋真美、石ヶ守里加子、武藤倫弘、今井俊夫
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      パシィフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-10-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 肥満モデルAyマウスにおける膵臓の脂肪浸潤のがんの発生・増殖に対する影響2016

    • Author(s)
      高橋真美、石ヶ守里加子、武藤倫弘、田中卓二、今井俊夫
    • Organizer
      がん予防学術大会2016名古屋
    • Place of Presentation
      名古屋大学基礎医学研究棟(愛知県・名古屋市)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Research-status Report
  • [Presentation] Increase of pancreatic cancer development in pancreas-specific K-ras mutant mice by crossing with obesity Ay mice and involvement of the M-CSF2016

    • Author(s)
      高橋真美、石ヶ守里加子、武藤倫弘、藤井元、宮本真吾、田中卓二、今井俊夫
    • Organizer
      第10回日米癌合同会議
    • Place of Presentation
      米国(ハワイ)
    • Year and Date
      2016-02-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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