Pancreatic cancer diagnostic markers of exsosome RNAs secreted from pancreatic cancer cells for clinical application
| Project/Area Number |
15K14396
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
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| Research Institution | Kochi University |
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Principal Investigator |
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| Research Collaborator |
TSUBOI Makiko
IWASAKI Shinji
OKABAYASHI Takehiro
SHIMA Yasuo
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 腫瘍診断学 / 腫瘍マーカー / 膵癌核酸腫瘍マーカー / 膵臓学 / 膵がん核酸腫瘍マーカー / 膵癌 / エクソソーム / 核酸診断マーカー |
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| Outline of Final Research Achievements |
In vitro experiments suggest that nine mRNAs were concentrated in intracellular exosomes in pancreatic cancer cells, and that these exosome-localized mRNAs were secreted from pancreatic cancer cells. A case-control study that included 20 patients with treatment-naive pancreatic cancer and 30 control individuals without pancreatic diseases was carried out. The nine mRNAs were measured from the purified serum exosomes in this cohort by real-time quantitative RT-PCR. The area under the receiver-operating characteristic curve (AUC) was as same as that of CA19-9 that is the clinical standard tumor biomarker for patients with pancreatic cancer. If some of these mRNAs were combined with CA19-9, the AUC was significantly higher compared with that for CA19-9 alone. Increased expression of serum exosome-localized mRNAs appears highly accurate in diagnosing pancreatic cancer.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Vav3 is linked to poor prognosis of pancreatic cancers and promotes the motility and invasiveness of pancreatic cancer cells.2016
Author(s)
Tsuboi M, Taniuchi K, Furihata M, Naganuma S, Kimura M, Watanabe R, Shimizu T, Saito M, Dabanaka K, Hanazaki K, Saibara T.
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Journal Title
Pancreatology.
Volume: 16
Issue: 5
Pages: 905-16
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells.2016
Author(s)
Tanouchi A, Taniuchi K, Furihata M, Naganuma S, Dabanaka K, Kimura M, Watanabe R, Kohsaki T, Shimizu T, Saito M, Hanazaki K, Saibara T.
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Journal Title
J Exp Clin Cancer Res.
Volume: 35
Issue: 1
Pages: 190-190
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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