Functional relationship between mRNA and divergently transcribed lncRNA
| Project/Area Number |
15K14397
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
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| Research Institution | Japanese Foundation for Cancer Research (2016)
Sapporo Medical University (2015) |
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Principal Investigator |
Maruyama Reo 公益財団法人がん研究会, がん研究所, プロジェクトリーダー (60607985)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 長鎖非コードRNA / lncRNA / がん |
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| Outline of Final Research Achievements |
Long non-coding RNA (lncRNA) has gained much attention due to its importance in every aspect of cellular and molecular processes. Recently, a lot of studies have reported a list of lncRNA genes whose expressions are dysregulated in cancer, however functions of these lncRNAs are largely unknown. In this study, we focused on pairs of mRNA and divergently transcribed lncRNAs in the same genomic region, and investigated whether there is a functional relationship between mRNA and divergently transcribed lncRNA. We first analyzed public and original expression dataset and finally selected one pair of mRNA and lncRNA for further functional analysis. We found that both the mRNA and the lncRNA have a function related to immune response, however at this point, we haven't have a evidence of functional relationship between them.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway.2016
Author(s)
Kurihara H, Maruyama R, Ishiguro K, Kanno S, Yamamoto I, Ishigami K, Mitsuhashi K, Igarashi H, Ito M, Tanuma T, Sukawa Y, Okita K, Hasegawa T, Imai K, Yamamoto H, Shinomura Y, Nosho K.
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Journal Title
Oncotarget
Volume: 7
Issue: 11
Pages: 12704-12717
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer.2016
Author(s)
Nosho K, Sukawa Y, Adachi Y, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yamamoto I, Ishigami K, Igarashi H, Maruyama R, Imai K, Yamamoto H, Shinomura Y.
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Journal Title
World J Gastroenterol
Volume: 22
Issue: 2
Pages: 557-566
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy.2015
Author(s)
Mitsuhashi K, Yamamoto I, Kurihara H, Kanno S, Ito M, Igarashi H, Ishigami K, Sukawa Y, Tachibana M, Takahashi H, Tokino T, Maruyama R, Suzuki H, Imai K, Shinomura Y, Yamamoto H, Nosho K.
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Journal Title
Oncotarget
Volume: 6
Pages: 22114-22125
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.2015
Author(s)
Su Y, Subedee A, Bloushtain-Qimron N, Savova V, Krzystanek M, Li L, Marusyk A, Tabassum DP, Zak A, Flacker MJ, Li M, Lin JJ, Sukumar S, Suzuki H, Long H, Szallasi Z, Gimelbrant A, Maruyama R, Polyak K.
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Journal Title
Cell Rep
Volume: 11
Issue: 10
Pages: 1549-1563
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway.2015
Author(s)
Ito M, Kanno S, Nosho K, Sukawa Y, Mitsuhashi K, Kurihara H, Igarashi H, Takahashi T, Tachibana M, Takahashi H, Yoshii S, Takenouchi T, Hasegawa T, Okita K, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y.
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Journal Title
Int J Cancer
Volume: 137
Issue: 6
Pages: 1258-1268
DOI
Related Report
Peer Reviewed
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