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Research directed toward developing immune-recovery treatment based on inhibiting a glycosidease

Research Project

Project/Area Number 15K14399
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Tumor diagnostics
Research InstitutionTokai University

Principal Investigator

Kanie Osamu  東海大学, 先進生命科学研究所, 教授 (90291062)

Co-Investigator(Renkei-kenkyūsha) INOUE Shigeaki  東海大学, 医学部, 准教授 (30582209)
TANAKA Katsunori  独立行政法人理化学研究所, 田中生体機能合成化学研究室, 準主任研究員 (00403098)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords高齢化 / がん / 敗血症 / 免疫療法 / 酵素阻害 / マクロファージ / マクロファージ活性化因子 / αガラクトサミニザーゼ / 酵素阻害剤 / αガラクトサミニダーゼ
Outline of Final Research Achievements

A partially truncated O-glycan-carrying Gc protein is known to activate immunity as GcMAF. It is expected that controlling the blood stability of GcMAF might affect the immune response against tumor. For this reason, a research directed toward finding a new therapeutic method based on inhibition of a key enzyme, α-GalNAc-ase was carried out.
Investigation of human α-GalNase activity and the inhibitory activity of a synthetic inhibitor revealed that the particular enzyme was stored in lysosome and was inhibited by the inhibitor. It is expected that the inhibitor molecule might be potent to maintain blood-GcMAF level. The presence of α-GalNAc structure in the GcMAF was also confirmed based on mass spectrometric analysis.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2018 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Addressing the glycan complexity by using mass spectrometry: In the pursuit of decoding glycologics2018

    • Author(s)
      Yoshimi Kanie and Osamu Kanie
    • Journal Title

      Biochemical Compounds

      Volume: 6 Pages: 1-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Introduction to the special issue on chemical glycobiology: all the aspects are important2015

    • Author(s)
      Osamu Kanie
    • Journal Title

      Glycoconjugate Journal

      Volume: 32 Issue: 7 Pages: 421-423

    • DOI

      10.1007/s10719-015-9623-5

    • Related Report
      2015 Research-status Report
    • Open Access
  • [Presentation] ガラクトース誘導体の立体特異的なTMS化反応2016

    • Author(s)
      浅見悠里、蟹江治
    • Organizer
      2016年度糖質科学合同セミナー
    • Place of Presentation
      清水
    • Year and Date
      2016-10-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 立体特異的TMSグリコシドの合成研究2016

    • Author(s)
      浅見悠里、河口優香、蟹江善美、蟹江治
    • Organizer
      第35回日本糖質学会年会
    • Place of Presentation
      高知
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Space, time and glycan processing: Synthetic and analytical approach.2016

    • Author(s)
      Osamu Kanie
    • Organizer
      XXVIIIth International Carbohydrate Symposium
    • Place of Presentation
      New Orleans
    • Year and Date
      2016-07-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2015-04-16   Modified: 2018-03-22  

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