| Project/Area Number |
15K14400
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
Shiba Kiyotaka 公益財団法人がん研究会, その他部局等, その他 (40196415)
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| Project Period (FY) |
2015-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | エクソソーム / 細胞外分泌小胞 / P-糖タンパク質 |
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| Outline of Final Research Achievements |
This research has confirmed that P-glycoprotein, which is known to be involved in multidrug resistance of cancer cell, is expressed on the exosomes that are released from the cells expressing P-glycoprotein. The conditions that allow specific fluorescence labelling of the P-glycoprotein-expressing exosomes using substrates of P-glycoprotein have been sought. However, sticky nature of exosomes under the assay conditions did not allow the establishment of the quantification method.
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