| Project/Area Number |
15K14402
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高見 誠一 東北大学, 多元物質科学研究所, 准教授 (40311550)
阿部 敬悦 東北大学, 農学研究科, 教授 (50312624)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHII Keiko 東北大学, 大学院医学系研究科, 准教授 (00291253)
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| Research Collaborator |
OKADA Hidechika 株式会社蛋白科学研究所
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ナノ粒子 / がん指向性 / アンチセンスペプチド / ステルスナノ粒子 / 相補性ペプチド |
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| Outline of Final Research Achievements |
In this study, for the development of a new cancer therapy, we conducted a study to develop a magnetite nanoparticles with active targeting ability against cancer cells using antisense peptides (AsPs), which are expected to accelerate the accumulation of these particles in the cancer tissues. We designed and generated Asps targeting HER2, which was involved in the growth of some breast cancer cells, and examined the effect of the AsPs on the growth of cancer cells and their binding capacity to these cells. Sixteen AsPs targeting the domain 2 of HER2 were designed and generated, and we have so far obtained one AsP showing the binding capacity to HER2-positive breast cancer cells among six AsPs affecting their growth. We are planning to introduce this AsP on the magnetite nanoparticles and examine their accumulation in the cancer tissues using tumor-bearing animals.
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