Molecular analysis of carcinogenesis based on genetic and environmental factors towards the development of new cancer therapeutics

• Project/Area Number: 15K14406
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor therapeutics
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Daigo Yataro 滋賀医科大学, 医学部, 教授 (30345029)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 分子標的治療

Outline of Final Research Achievements

To establish new cell and molecular assays that enable us to clarify the mechanism of carcinogenesis based on genetic and environmental factors and to develop new cancer therapeutics, we screened for several cancer-related genes and examined their molecular dynamics using the cancer cells in which the expression of these genes can be controlled. As a result, we could get basic information for new knowledge of carcinogenesis and for new anti-cancer drug development targeting the cancer-related genes. We reported the results of this study at various conferences and published some manuscripts in international academic journals.

Research Products

• [Int'l Joint Research] NIH(米国)
• [Int'l Joint Research] NIH(米国)
• [Journal Article] Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer. (2018)
  • Author(s): Daigo K, Takano A, Thang PM, Yoshitake Y, Shinohara M, Tohnai I, Murakami Y, Maegawa J, Daigo Y.
  • Journal Title: Int J Oncol. Volume: 52(1) Pages: 155-165
  • DOI: 10.3892/ijo.2017.4181
  • Peer Reviewed / Open Access
• [Journal Article] The mechanism of de novo expression of programmed cell death-ligand 1 in squamous cell carcinoma of the lung (2017)
  • Author(s): Tomoyuki Igarashi, Koji Teramoto, Mitsuaki Ishida, Jun Hanaoka, Yataro Daigo
  • Journal Title: Oncology Reports Volume: 38 Issue: 4 Pages: 2189-2196
  • DOI: 10.3892/or.2017.5876
  • Peer Reviewed / Open Access
• [Journal Article] Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. (2017)
  • Author(s): Seow WJ, Matsuo K, Hsiung CA, Shiraishi K, et al
  • Journal Title: Hum Mol Genet. Volume: 26(2) Pages: 454-465
  • DOI: 10.1093/hmg/ddw414
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. (2016)
  • Author(s): Shiraishi K, Okada Y 他44名 Inazawa J 38番目
  • Journal Title: Nat Commun. Volume: 7 Issue: 1 Pages: 12451-12451
  • DOI: 10.1038/ncomms12451
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. (2016)
  • Author(s): Wang Z, Seow WJ, Shiraishi K, Hsiung CA, Matsuo K, Liu J, Chen K, Yamji T, Yang Y, Chang IS, Wu C, Hong YC, Burdett L, Wyatt K, Chung CC, Li SA, Yeager M, Hutchinson A, Hu W, Caporaso N, Landi MT, Chatterjee N, Song M, Fraumeni JF Jr, Kohno T, Yokota J, Kunitoh H, Ashikawa K, Momozawa Y, Daigo Y, et al.
  • Journal Title: Hum Mol Genet Volume: 25 Issue: 3 Pages: 620-629
  • DOI: 10.1093/hmg/ddv494
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] がんの分子病態に基づいたトランスレーショナルリサーチと創薬開発 (2018)
  • Author(s): 醍醐 弥太郎
  • Organizer: 第32回札幌冬季がんセミナー
  • Invited
• [Presentation] Integrated genomics-based discovery of new biomarkers for lung cancer. (2015)
  • Author(s): 醍醐 弥太郎
  • Organizer: 第74回日本癌学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-10-10
  • Invited
• [Book] 日本胸部臨床 (2016)
  • Author(s): 醍醐 弥太郎
  • Total Pages: 202
  • Publisher: 克誠堂出版