Molecular analysis of carcinogenesis based on genetic and environmental factors towards the development of new cancer therapeutics
| Project/Area Number |
15K14406
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Daigo Yataro 滋賀医科大学, 医学部, 教授 (30345029)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 分子標的治療 |
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| Outline of Final Research Achievements |
To establish new cell and molecular assays that enable us to clarify the mechanism of carcinogenesis based on genetic and environmental factors and to develop new cancer therapeutics, we screened for several cancer-related genes and examined their molecular dynamics using the cancer cells in which the expression of these genes can be controlled. As a result, we could get basic information for new knowledge of carcinogenesis and for new anti-cancer drug development targeting the cancer-related genes. We reported the results of this study at various conferences and published some manuscripts in international academic journals.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women.2016
Author(s)
Wang Z, Seow WJ, Shiraishi K, Hsiung CA, Matsuo K, Liu J, Chen K, Yamji T, Yang Y, Chang IS, Wu C, Hong YC, Burdett L, Wyatt K, Chung CC, Li SA, Yeager M, Hutchinson A, Hu W, Caporaso N, Landi MT, Chatterjee N, Song M, Fraumeni JF Jr, Kohno T, Yokota J, Kunitoh H, Ashikawa K, Momozawa Y, Daigo Y, et al.
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Journal Title
Hum Mol Genet
Volume: 25
Issue: 3
Pages: 620-629
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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