Mutual exclusiveness of driver oncogenes
| Project/Area Number |
15K14412
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
KATAYAMA Ryohei 公益財団法人がん研究会, がん化学療法センター 基礎研究部, 主任研究員 (60435542)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJITA NAOYA 公益財団法人がん研究会, がん化学療法センター, 所長 (20280951)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 分子標的治療 / 肺腺がん / がん遺伝子 / 相互排他性 / チロシンキナーゼ / 過剰活性化 / 細胞死 / がん / Driver oncogene |
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| Outline of Final Research Achievements |
Along with the progress of genome sequencing with next generation sequencers, genetic abnormalities in cancer have been extensively uncovered. As the results of the comprehensive sequencing of cancer genome, it is known that driver oncogene mutation is mutually exclusive, but its reason has not been covered yet. In this study, we found that the excessively upregulate driver oncogene derived signaling induce cell death instead of cell proliferation using ROS1 fusion oncogene induced cells. We also found the key pathway and molecules which are related to trigger cell death when the driver oncogene signaling became excessive.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] APC mutations as a predictive biomarker for sensitivity to tankyrase inhibitors in colorectal cancer.2017
Author(s)
Noritaka Tanaka, Tetsuo Mashima, Anna Mizutani, Ayana Sato, Aki Aoyama, Bo Gong, Haruka Yoshida, Yukiko Muramatsu, Kento Nakata, Masaaki Matsuura, Ryohei Katayama, Satoshi Nagayama, Naoya Fujita, Yoshikazu Sugimoto, Hiroyuki Seimiya
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Journal Title
Mol. Cancer Ther.
Volume: 16
Issue: 4
Pages: 739-751
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] P-glycoprotein mediates ceritinib resistance in anaplastic lymphoma kinase-rearranged non-small cell lung cancer.2016
Author(s)
Katayama R*, Sakashita T, Yanagitani N, Ninomiya H, Horiike A, Friboulet L, Gainor JF, Motoi N, Dobashi A, Sakata S, Tambo Y, Kitazono S, Sato S, Koike S, Iafrate AJ, Mino-Kenudson M, Ishikawa Y, Shaw AT, Engelman JA, Takeuchi K, Nishio M*, Fujita N*
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Journal Title
EBioMedicine
Volume: 3
Pages: 54-66
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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