| Project/Area Number |
15K14416
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | Nagasaki University |
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Principal Investigator |
MASUTANI Mitsuko 長崎大学, 医歯薬学総合研究科(医学系), 教授 (60238904)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIMORI Hiroaki 国立研究開発法人国立がん研究センター, 研究所, 研究員 (00590043)
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| Research Collaborator |
ONODERA Takae
SASAKI Yuka
HIRAI Takahisa
IMAMICHI Shoji
KIKUHARA Sota
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | PARP / radiosensitization / DNMT3b / gamma-irradiation / cancer / 放射線感受性 / 網羅的探索 / 放射線増感 / ガンマ線 / PARP阻害剤 / 陽子線 / DNMT3B / HP1beta / gamma H2AX |
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| Outline of Final Research Achievements |
A comprehensive genome-wide screen of radiosensitization targets in cancer cells using an shRNA-library has been performed and some genes were identified as candidate target. Among them, we focused on the DNMT3b, poly(ADP-ribose) polymerase1 (PARP-1)、interleukin 27 receptor, alpha (IL27RA) and APOBEC3G. These genes were suggested as potential targets of radiosensitization.
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