| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Based on our previous data that ASK1 knockout mice are highly resistant to tumor metastasis, we investigated in which cells ASK1 functions during metastasis with focusing on the molecular mechanisms. Using tissue-specific conditional knockout mice, we revealed that ASK1 in multiple cells, at least in the platelet and the endothelial cells, is involved in tumor metastasis. Furthermore, ASK1-knockout platelets showed deficiency in multiple kinase signal transductions, resulting in the defect in platelet functions. Also, we found that a phosphorylation site in an ADP receptor P2Y12 was attenuated in ASK1-deficient platelets, which is attributable to the defect of a kinase signal transduction.
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