| Project/Area Number |
15K14449
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ストレス反応 / 分裂酵母 / 変異体スクリーニング / ストレス / ミトコンドリア / 暦寿命 / ミトコンドリアDNA / 制限酵素 |
|---|
| Outline of Final Research Achievements |
All organisms live in ever-changing environments. Subtle environmental stresses, although not recognized consciously, may alert organisms to prepare for prospective severe stress. This study is aimed for elucidating molecular pathways, if any, that recognizes low-dose stress, which causes adaptive response in organisms. We have screened fission yeast a mutant library for mutants that are resistant to severe stress, but sensitive to low-dose stress. We have identified mutants and their responsible genes. These results suggest that there is pathawys that respond specifically to low-dose stresses.
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