| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
We inspected a hypothesis that long analog-like signals by receptors in cell plasma membranes can be generated by summation of short digital-like signals. We performed single-molecule imaging of recruitment of signaling molecules to EGF receptors upon ligation, and found that the recruitment occurred for very short periods (less than 0.5 sec), but the frequency of the recruitment was increased as the bulk signal intensity was increased. These results strongly support the hypothesis.
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