Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Outline of Final Research Achievements |
We have revealed that the antioxidative functions of SOD3 were modulated by N-glycans carried on them. SOD3 lacking complex type glycans expressed different anticancer effects compared with SOD3 carrying complex type glycans, which indicated N-glycans on SOD3 were involved in development of cancers. We also revealed that oxidative stress changed the expression levels of multiple glycosyltransferases in macrophage, which enhanced phagocytosis. These results demonstrate the biological linkage between glycans and redox. We are now trying to publish these results.
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