Construction of DNA origami base gene transcription nano chip
| Project/Area Number |
15K14485
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Osaka University (2016)
Kyoto University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 1分子計測・操作 / ナノマシン / 蛋白質 / 核酸 / 1分子計測(SMD) / 分子機械 / マイクロ・ナノデバイス |
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| Outline of Final Research Achievements |
Toward the handheld device, downsizing the subcomponent system is the key. Here,we made an orthogonal self-contained device by integrating an enzyme, T7 RNA polymerase, and multiple target gene substrates onto a DNA origami-based nano-chip.Our nano-chip allowed us to rationally design the gene expression at single chip level, suggesting that the integrated approach may provide a basis for gene expression system of handheld devices.
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Report
(3 results)
Research Products
(14 results)
