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Nematodes as a model system for studying evolution of diverse microtubule behaviors

Research Project

Project/Area Number 15K14503
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cell biology
Research InstitutionTohoku University

Principal Investigator

Sugimoto Asako  東北大学, 生命科学研究科, 教授 (80281715)

Research Collaborator KUBOTA Yukihiko  東北大学, 大学院生命科学研究科, 助教 (70333325)
HONDA Yu  東北大学, 大学院生命科学研究科, 大学院生
NAMAI Satoshi  東北大学, 大学院生命科学研究科, 大学院生
TSUYAMA Kenji  東北大学, 大学院生命科学研究科, 大学院生
TSUCHIYA Kenta  東北大学, 大学院生命科学研究科, 大学院生
KUMAGAI Ryohei  東北大学, 大学院生命科学研究科, 大学院生
OBINATA Hiroyuki  東北大学, 理学部生物学科, 学部学生
SASAKI Daichi  東北大学, 理学部生物学科, 学部学生
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords微小管 / 線虫 / 進化 / C. elegans / P. pacificus / C.elegans / P.pacificus / アクチン / 細胞極性 / 進化細胞生物学 / CRISPR/Cas9
Outline of Final Research Achievements

In this study, we established a model system for “evolutionary cell biology” using nematode Caenorhabditis elegans and Pristionchus pacificus. By live imaging of microtubules and actin filaments, we found that the timing of microtubule assembly/disassembly is different in these two nematodes, which correlates with distinct mitotic spindle behaviors and cell polarity establishment mechanisms.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 Other

All Int'l Joint Research (2 results) Presentation (6 results) (of which Int'l Joint Research: 4 results)

  • [Int'l Joint Research] マックス・プランク発生生物学研究所(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Max-Planck Institute for Dev. Biol.(ドイツ)

    • Related Report
      2015 Research-status Report
  • [Presentation] 進化細胞生物学のモデル系としての線虫2016

    • Author(s)
      杉本亜砂子
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Comparative analysis of germ granules between Ceanorhabditis elegans and its sister species Caenorhabditis sp.342016

    • Author(s)
      Ryouhei Kumagai
    • Organizer
      7th Asia-Pacific C.elegans Meeting
    • Place of Presentation
      Beijing, China
    • Year and Date
      2016-06-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distinct microtubule behaviors in zygotes of Caenorhabditis elegans and Pristionchus pacificus2016

    • Author(s)
      Satoshi Namai and Asako Sugimoto
    • Organizer
      Caenorhabditis and other Nematodes Meeting
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Year and Date
      2016-04-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distinct microtubule behaviors in zygotes of Caenorhabditis elegans and Pristionchus pacificus2016

    • Author(s)
      Satoshi Namai, Asako Sugimoto
    • Organizer
      Evolutionary biology of Caenorhabditis and other nematodes
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Caenorthabditis sp.34 is a sister species to C.elegans with marked differences in morphology and ecology2016

    • Author(s)
      Asako Sugimoto
    • Organizer
      7th Asia-Pacific C.elegans Meeting
    • Place of Presentation
      Beijing, China
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 線虫C.elegansとP.pacificusの細胞分裂様式の比較解析2015

    • Author(s)
      生井 聡史、久保田 幸彦、杉本 亜砂子
    • Organizer
      日本動物学会平成 27 年度東北支部大会
    • Place of Presentation
      東北大学農学部(宮城県仙台市)
    • Year and Date
      2015-08-08
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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