| Project/Area Number |
15K14513
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脂質代謝 / 脂肪細胞 / イメージング / Aquaporin / 代謝 / 脂質 / 脂肪分解 |
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| Outline of Final Research Achievements |
In this study, we developed techniques of imaging for fat metabolism in tissue and single cells, and found the mechanism of fat storage modulation by AQP7. The generation and degradation of triglycerides are regulated by the dynamic subcellular localization of AQP7 in mouse white adipose tissue and single adipocytes. The expression and localization of the adipocyte proteins are controlled by the AQP7 signaling. AQP7 is centrally involved in lipid storage management supported by the observation that AQP7-null mice exhibit marked hypertrophy of adipose tissue, obesity and diabetes. We recently found that AQP7 was relocalized from the plasma membrane to intracellular regions during catecholamine-induced lipolysis in white adipocytes. These functions suggested a potential treatment for metabolic disorders: the pharmacological modulation of the AQP7-mediated lipid storage regulation.
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| Academic Significance and Societal Importance of the Research Achievements |
白色脂肪組織の脂肪細胞は、脂肪の合成蓄積と分解放出により全身のエネルギー代謝の恒常性を担保し、かつ各種ホルモンを放出することで全身の代謝制御に関与する。脂肪代謝を改善させる手段として、脂肪の合成蓄積と分解放出とのバランスに係る経路の重要性が本研究により明らかになった。ヒトの白色脂肪細胞において当該のバランス調整経路を制御する薬剤の、糖尿病への治療効果、さらにはがんや精神神経疾患の治療や予防への応用が期待される。
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