| Project/Area Number |
15K14534
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Okuda Satoru 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, 基礎科学特別研究員 (80707836)
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| Co-Investigator(Kenkyū-buntansha) |
橋本 敦史 京都大学, 教育学研究科, 助教 (80641753)
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| Co-Investigator(Renkei-kenkyūsha) |
EIRAKU Mototsugu 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, チームリーダー (40415097)
MORI Shunsuke 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, 研究員 (90733147)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 三次元バーテックスモデル / 器官形成 / バイオメカニクス / ３次元バーテックスモデル / バイオメカ二クス |
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| Outline of Final Research Achievements |
This study aims to develop a method to simulate tissue morphogenesis based on experimentally observed morphological data using the 3D vertex model. Moreover, by comparing the in-vivo and in-silico deformation processes quantitatively, we predicted several key mechanisms to drive the tissue morphogenesis. First, we deloped the mathematical model of cell apoptosis based on the 3D vertex model framework. Next, by applying the developed model to the optic-cup morphogenesis, we qualitatively predicted the mechanisms of the tissue morphogenesis.
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