| Project/Area Number |
15K14560
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphology/Structure
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| Research Institution | Okayama University |
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Principal Investigator |
satoh akira 岡山大学, 異分野融合先端研究コア, 准教授 (90512004)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 四肢再生 / 尾部再生 / レンズ再生 / FGF / BMP / 器官再生 / メキシコサラマンダー / 過剰肢付加モデル / 再生因子 / 神経 |
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| Outline of Final Research Achievements |
In our previous study, we found that BMP7+FGF2+FGF8 can induce limb regeneration. This protein cocktail is actually the limb regeneration inducer in some species. We applied our-defined protein cocktail into other organs. Eye (lens) and tail regeneration were focused. We found that BMP7+FGF2+FGF8 application could induce tail regeneration in urodele amphibians. Regarding to the lens regeneration in an axolotl, the protein combination could induce lens regeneration with very low success rate. However, due to the low induction rate, we still need further confirmation on this point. The detail molecular mechanism, which underlies general organ regeneration ability, has still been unknown.However, the results in the present study successfully provides fundamental insights. We are heading further investigation to identify the molecular entities of organ regeneration ability.
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