| Project/Area Number |
15K14566
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | University of Tsukuba |
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Principal Investigator |
INABA Kazuo 筑波大学, 生命環境系, 教授 (80221779)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBA Kogiku 筑波大学, 生命環境系, 助教 (70533561)
HIROSE Keiko 国立研究開発法人産業総合研究所, バイオメディカル研究部門, 主任研究員 (90357872)
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| Research Collaborator |
KUTOMI Osamu
JOKURA Kei
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | DYBLUP / ダイニン / BLUP / 光応答 / 鞭毛 / 繊毛 / 精子 / クラミドモナス / 青色光 / 光受容 / 繊毛運動 / ホヤ / 微小管 |
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| Outline of Final Research Achievements |
This research project was carried out to clarify the molecular nature and mechanism of a novel dynein photoreceptor DYBLUP. The 2 years project showed (1) the molecule of f/I1 dynein form ascidian sperm is similar to that from Chlamydomonas flagella, (2) ascidian DYBLUP is bound to the motor region of f/I1, (3) the protein product of a gene (MOT7) orthologous to DYBLUP is also present in Chlamydomonas flagella, (5) a Chlamydomonas mutant lacking DYBLUP/MOT7 shows suppressed positive phototaxis and the turn movement in photoshock reaction.
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