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Elucidation of degeneration process of the Y chromosome by using the neo-sex chromosome systems in Drosophila species

Research Project

Project/Area Number 15K14585
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Evolutionary biology
Research InstitutionTokyo Metropolitan University (2016)
National Institute of Genetics (2015)

Principal Investigator

Nozawa Masafumi  首都大学東京, 理工学研究科, 助教 (50623534)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords性染色体 / ショウジョウバエ / 次世代シーケンサー / Y染色体 / サイレンシング / ゲノム / トランスクリプトーム / 遺伝子退化 / 昆虫 / 染色体退化 / 遺伝子発現
Outline of Final Research Achievements

Sex chromosomes derived from a pair of autosomes provide a stable sex-determination to organisms, but result in a massive loss of functional genes on the Y chromosome, which is potentially deleterious. Despite this complicated outcomes, organisms have repeatedly and independently acquired sex chromosomes during evolution. A promising approach to solve this “paradox” is to uncover the degeneration process of the Y. In this study, I determined the genome sequences of three Drosophila species that recently acquired sex chromosomes and those of their closely-related species, and clarified the degeneration process of these Y chromosomes. The analyses revealed that the extent of Y degeneration does not necessarily proportional to the Y age. This finding implies that the initial Y dynamics after its emergence is largely governed by chromatin modification, resulting in rapid reversible gene silencing. This study poses a new concept with respect to the initial stage of Y “degeneration”.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 Other

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Invited: 3 results) Remarks (1 results)

  • [Journal Article] Accelerated pseudogenization on the neo-X chroosome in Drosophila miranda2016

    • Author(s)
      Nozawa M, Onizuka K, Fujimi M, Ikeo K, and Gojobori T
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 13659-13659

    • DOI

      10.1038/ncomms13659

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 性染色体化はY染色体だけでなくX染色体の退化も引き起こす?:ショウジョウバエNeo性染色体を用いた検証2017

    • Author(s)
      野澤昌文
    • Organizer
      性と生殖の懇談会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2017-01-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 性染色体の進化:なぜ多くの生物が性染色体を持つのか?2016

    • Author(s)
      野澤昌文
    • Organizer
      第88回日本遺伝学会
    • Place of Presentation
      日本大学三島キャンパス
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 性染色体の退化過程の解明:ORFの破損?それとも転写の停止?2016

    • Author(s)
      野澤昌文
    • Organizer
      第18回日本進化学会
    • Place of Presentation
      東京工業大学大岡山キャンパス
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 性染色体と性的拮抗の進化2016

    • Author(s)
      野澤昌文
    • Organizer
      遺伝研研究集会・分子進化学の現状と今後の展望
    • Place of Presentation
      国立遺伝学研究所
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Remarks] 首都大学東京生命科学コース進化遺伝学研究室

    • URL

      http://www.biol.se.tmu.ac.jp/labo.asp?ID=evogen

    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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