| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Outline of Final Research Achievements |
This study aimed to unveil early stages of adaptive evolution of eukaryotes to anaerobiosis, using a eukaryote that is capable of thriving in both aerobic and anaerobic conditions. Mitochondria-targeting proteins were identified by transcriptome analyses followed by localization studies. Comparative transcriptome analyses revealed that mitochondrial energy producing pathways are drastically different between aerobic and anaerobic conditions. Molecular phylogenetic analyses suggested those genes encoding the mitochondrial anaerobic energy production had been acquired by lateral transfers. On the basis of findings in this study, important steps for early stages of evolutionary adaptation to anaerobiosis in eukaryotes were suggested to be acquisition of genes for mitochondrial anaerobic energy production and transcriptional regulation of those genes in different oxygen concentrations.
|
