Epigenome anthropology: aiming for a better understanding of human phenotypic variation
Project/Area Number |
15K14612
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Physical anthropology
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Research Institution | The University of Tokyo (2017) Jichi Medical University (2015-2016) |
Principal Investigator |
Kazuhiro Nakayama 東京大学, 大学院新領域創成科学研究科, 准教授 (90433581)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | エピジェネティクス / 環境適応 / ヒト / 遊牧 / 農耕 / DNAメチル化 / モンゴル人 / タイ人 / 栄養 / 人類学 |
Outline of Final Research Achievements |
To evaluate the influence of differences in traditional life styles on epigenetic information and phenotypic diversity, We compared the genome - wide methylation levels of the peripheral blood DNA of 48 individuals from Mongolians (nomadic pastoralists) and Thai (agriculturalist). As a result, it was revealed that the CpG sequences near the promoter of the genes contributing to energy metabolism systems, such as the AMP activated protein kinase pathways and the peroxisome proliferator-activated receptor pathways, showed a large difference in methylation level.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Influence of AHRR Pro189Ala polymorphism on kidney functions. Biosci Biotech Biochem.2017
Author(s)
Nakayama K, Saito S, Watanabe K, Miyashita H, Nishijima F, Kamo Y, Tada K, Ishizuka S, Niwa T, Iwamoto S, Shimizu H
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Journal Title
Biosci Biotech Biochem
Volume: Published online
Issue: 6
Pages: 1120-1124
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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