The relationship between a gene associated with sweat gland and sweating function in humans

• Project/Area Number: 15K14618
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied anthropology
• Research Institution: Kobe University
• Principal Investigator: Kondo Narihiko 神戸大学, 人間発達環境学研究科, 教授 (70215458)
• Co-Investigator(Kenkyū-buntansha): 井上 芳光 大阪国際大学, 人間科学部, 教授 (70144566) ; 前田 享史 九州大学, 芸術工学研究院, 教授 (90301407)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 発汗機能 / 遺伝子 / ヒト / 遺伝

Outline of Final Research Achievements

To investigate a relationship between sweating function and EDAR370A gene associated with activated sweat gland in humans, we compared activated sweat gland and sweat function in a subject with EDAR370A with a subject without this gene. We recruited 40 healthy subjects (age range of 20-80 years old). We found only 4 subjects with EDAR370A. Although number of activated sweat glands in the subjects with EDAR370A gene tended to be greater than that in the subjects without this gene, sweat function was not markedly different between the groups. However, we could not conclude the effect of EDAR370A on human sweat function because sample size of subjects without EDAR370A was extremely small.

Research Products

• [Journal Article] 運動時におけるヒトの発汗調節特性 (2017)
  • Author(s): 近藤徳彦，天野達郎，Nicola Gerrett
  • Journal Title: 発汗学 Volume: 24 Pages: 2-5
• [Journal Article] Maximum rate of sweat ions reabsorption during exercise with regional differences, sex, and exercise training. (2017)
  • Author(s): Amano T, Hirose M, Konishi K, Gerrett N, Ueda H, Kondo N, Inoue Y
  • Journal Title: Eur J Appl Physiol Volume: 117 Issue: 7 Pages: 1317-1327
  • DOI: 10.1007/s00421-017-3619-8
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Characteristics of sweating response in habitually trained individuals and its potential mechanisms (2017)
  • Author(s): Amano T, Kondo N
  • Organizer: The 17th International Conference on Environmental Ergonomics
  • Int'l Joint Research / Invited
• [Presentation] Sweat glands ion reabsorption (2017)
  • Author(s): Gerrett N, Amano T, Kondo N
  • Organizer: The 17th International Conference on Environmental Ergonomics
  • Int'l Joint Research / Invited
• [Presentation] 運動時におけるヒトの発汗調節特性 (2016)
  • Author(s): 近藤徳彦，天野達郎，Nicola Gerrett
  • Organizer: 第24回日本発汗学会総会
  • Place of Presentation: 大阪大学医学系研究科（大阪府・吹田市）
  • Year and Date: 2016-08-27
  • Invited
• [Presentation] Thermoregulation in the tropics (2015)
  • Author(s): Kondo N, Amano T, Inoue Y, Nishiyasu
  • Organizer: The 8th the Asian and Oceanian Physiological Societies (FAOPS) Congress
  • Place of Presentation: Banckok, Thaihland
  • Year and Date: 2015-11-22
  • Int'l Joint Research / Invited
• [Presentation] Integrated control of heat loss responses during exercise in humans (2015)
  • Author(s): Kondo N, Amano T, Inoue Y, Nishiyasu T
  • Organizer: International Conference on Movement, Health & Exercise 2015
  • Place of Presentation: Penang, Malaysia
  • Year and Date: 2015-10-05
  • Int'l Joint Research / Invited
• [Presentation] Changes in heat loss responses with exercise training (2015)
  • Author(s): Kondo N, Amano T, Inoue Y, Nishiyasu T
  • Organizer: International Conference on Movement, Health & Exercise 2015
  • Place of Presentation: Penang, Malaysia
  • Year and Date: 2015-10-05
  • Int'l Joint Research / Invited