Ecophysiolosical consequences of chronic ethanol consumption on human gut microbiota: implications for the pathogenesis of ethanol-related colorectal cancer
Project/Area Number |
15K14682
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Applied microbiology
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Research Institution | Tohoku University |
Principal Investigator |
Nakayama Toru 東北大学, 工学研究科, 教授 (80268523)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | acetaldehyde / alcoholism / gut microbiota / intestinal bacteria / 習慣的多量飲酒 / 大腸がん / 腸内細菌 / アセトアルデヒド / 酸化ストレス / 活性酸素 / 菌叢構造 / アルコール依存症 |
Outline of Final Research Achievements |
To find roles of gut microbes and their acetaldehyde metabolism in the pathogenesis of ethanol-related colorectal cancer, the gut microbiota structures of non-alcoholics and alcoholics were analyzed and compared. The gut microbiotas of alcoholics were diminished in dominant obligate anaerobes and enriched in Streptococcus and other minor species. This alteration might be exacerbated by habitual smoking. These observations could at least partly be explained by the susceptibility of obligate anaerobes to reactive oxygen species, which are increased by chronic exposure of the gut mucosa to ethanol. The acetaldehyde productivity from ethanol was much lower in the faeces of alcoholic patients than in faeces of non-alcoholic subjects. Based on these results, a model has been proposed, in which oxidative dress induced upon chronic ethanol consumption serves as an important risk factor in the pathogenesis of ethanol-related colorectal cancer.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Major Anaerobic Bacteria Responsible for the Production of Carcinogenic Acetaldehyde from Ethanol in the Colon and Rectum2016
Author(s)
Atsuki Tsuruya, Akika Kuwahara, Yuta Saito, Haruhiko Yamaguchi, Natsuki Tenma, Makoto Inai, Seiji Takahashi, Eri Tsutsumi, Yoshihide Suwa, Yukari Totsuka, Wataru Suda, Kenshiro Oshima, Masahira Hattori, Takeshi Mizukami, Akira Yokoyama, Takefumi Shimoyama, and Toru Nakayama
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Journal Title
Alcohol and Alcoholism
Volume: 未定
Issue: 4
Pages: 395-401
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ecophysiological consequences of alcoholism on human gut microbiota: implications for ethanol-related pathogenesis of colon cancer2016
Author(s)
A. Tsuruya, A. Kuwahara, Y. Saito, H. Yamaguchi, T. Tsubo, S. Suga, M. Inai, Y. Aoki, S. Takahashi, E. Tsutsumi, Y. Suwa, H. Morita, K. Kinoshita, Y. Totsuka, W. Suda, K. Oshima, M. Hattori, T. Mizukami, A.Yokoyama, T. Shimoyama & T. Nakayama
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 27923-27923
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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