Specific secretory production system of D-amino acid derivatives by budding yeast and its application for their fermentation production
| Project/Area Number |
15K14699
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied microbiology
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | D-アミノ酸 / 出芽酵母 / N-アセチル-D-アミノ酸 / D-アミノアシラーゼ / アミノ酸ラセマーゼ / D-アミノアセチルトランスフェラーゼ / 発酵生産 / D-アミノ酸アセチルトラン スフェラーゼ / D-アミノ酸アセチルトランスフェラーゼ / N-アセチル－D-アミノ酸 |
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| Outline of Final Research Achievements |
D-amino acids might be the presence of the shade in comparison with L-amino acids. Recently, however, it has been clarified that some D-amino acids play essential roles in the brain functions in mammals. In addition, therapeutic drugs such as antibiotics require D-amino acids as components. In this research project, potential fermentation production of D-amino acid derivatives has been investigated and its feasibility as one of the D-amino acid production methods has been evaluated. We showed the result that D-amino acid derivatives produced by fermentation method were enzymatically converted to D-amino acids.
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Report
(4 results)
Research Products
(4 results)
