| Project/Area Number |
15K14706
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied biochemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MITANI Tasuku 近畿大学, 先端技術総合研究所, 教授 (10322265)
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| Research Collaborator |
Heinis Christian École Polytechnique Fédérale de Lausanne
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 細胞核 / クロマチン / 遺伝子発現 / アクチンファミリー / エピジェネティクス / 遺伝子初期化 / アクチン / 核内アクチン / クロマチンリモデリング |
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| Outline of Final Research Achievements |
In this project, we showed that artificial nuclear F-actin associates with chromatin and that nuclear F-actin affects Wnt/beta-catenin signaling, which has important roles on gene reprogramming and cell development. Indeed, the expression of OCT4 is shown to be regulated by nuclear F-actin. By screening a peptide library, we identified bicyclic peptides binding to G- or F-actin. We also showed a possibility that these bicyclic peptides are useful for artificial regulation of nuclear F-actin.
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