| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Protein myristoylation is an irreversible lipid modification and demyristoylation enzymes have not yet been identified. Since many myristoylated proteins are important for disease pathogenesis, it is a major finding to clarify the presence of demyristoylation enzymes involved in the regulation of myristoylated proteins.
In this study, we aimed to purify and identify the demyristoylation enzyme and to clarify its enzymatic caharacteristics. As a result, we succeeded in finding demyristoylation activity from rat brain soluble fraction. In this research process, we also developed an assay system to identify demytostroylation activity.
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