| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Total synthetic studies on amphirionin-4 (1) and amphirionin-5 (2), which exhibit potent proliferation-promoting activity on osteoblastic cells and related cells, were conducted. As for 1, its expeditions enantioselective total synthesis was achieved by an 8-pot sequence that features a concise construction of an all-cis trisubstituted THF ring using a diastereoselective iodoetherification and a lactone-forming intramolecular alkylation to connect the left-hand and central moieties of the target molecule. Our efforts toward the preparation of the C1-C8 fragment of 2 are now underway.
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