Synthetic studies on marine-derived polyketides that exhibit proliferation-promoting activity on osteoblastic cells and bone marrow stromal cells
| Project/Area Number |
15K14718
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | amphirionin / total synthesis / osteoblast / polyketide / 生体分子 / 生理活性 / 有機化学 |
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| Outline of Final Research Achievements |
Total synthetic studies on amphirionin-4 (1) and amphirionin-5 (2), which exhibit potent proliferation-promoting activity on osteoblastic cells and related cells, were conducted. As for 1, its expeditions enantioselective total synthesis was achieved by an 8-pot sequence that features a concise construction of an all-cis trisubstituted THF ring using a diastereoselective iodoetherification and a lactone-forming intramolecular alkylation to connect the left-hand and central moieties of the target molecule. Our efforts toward the preparation of the C1-C8 fragment of 2 are now underway.
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Report
(3 results)
Research Products
(5 results)
