Elucidation of cellular uptake of curcumin: its relation to biological activity
| Project/Area Number |
15K14725
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宮澤 陽夫 東北大学, 農学研究科, 教授 (20157639)
木村 ふみ子 尚絅学院大学, 公私立大学の部局等, 准教授 (50321980)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | クルクミン / 生物学的利用能 / ナノ粒子 / 細胞内移行 / アルブミン / 吸収代謝 / LC-MS/MS / 生理作用発現機構 / 食品機能 |
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| Outline of Final Research Achievements |
Curcumin (CUR) has been known to have various biological activity, whereas bioavailability of CUR is low. It is still unclear whether CUR itself and/or metabolites are responsible for the biological activity in vivo. We hypothesized that preferential uptake of CUR by cultured cells determine its biological activity. To evaluate this, we performed cell culture studies. Using HPLC, it was revealed the uptake of CUR by cultural cells was high, whereas that of CUR related compounds was low. Hence, the remarkable differential cellular uptake of CUR, relative to the related compounds, would determine the biological activity of CUR. Our ongoing studies showed that the differential uptake may occur via interaction of CUR with a medium component, albumin. In addition, we are performing experiments about CUR nanoformulation in order to increase bioavailability of CUR. Our studies will provide a better understanding of the bioavailability and biological activity of CUR for nutraceutical purposes.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Modulation of cAMP levels by high fat diet and curcumin and regulatory effects on CD36/FAT scavenger receptor/fatty acids transporter gene expression.2017
Author(s)
Zingg, J.M., Hasan, S.T., Nakagawa, K., Canepa, E., Ricciarelli, R., Villacorta, L., Azzi, A., Meydani, M.
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Journal Title
BioFactors.
Volume: 43
Issue: 1
Pages: 42-53
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Metabolic fate of poly-(lactic-co-glycolic acid)-based curcumin nanoparticles following oral administration.2016
Author(s)
Harigae, T., Nakagawa, K., Miyazawa, T., Inoue, N., Kimura, F., Ikeda, I., Miyazawa, T.
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Journal Title
Int. J. Nanomedicine
Volume: 11
Pages: 3009-3022
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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