| Project/Area Number |
15K14726
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
仲川 清隆 東北大学, 農学研究科, 教授 (80361145)
木村 ふみ子 尚絅学院大学, 総合人間科学部, 准教授 (50321980)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ラット / フォーカストアレイ / 脂肪肝 / 過酸化脂質 / マイクロアレイ / 食品学 / 動物実験 |
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| Outline of Final Research Achievements |
Fatty liver is a risk factor for steatohepatitis, hepatic cirrhosis and hepatoma, thus increasing nonalcoholic fatty liver disease related with obesity is becoming a problem. This study examined animal model and analysis method for the elucidation of the multifactorial mechanism leading nonalcoholic steatohepatitis development, and prevention by food component. Liver mRNA of rat examined by the focused microarray analysis. High fat diet fed rats with high value of serum liver disorder marker and fatty liver accompanied the increment of mRNA expression of cytokine related on initial stage of the inflammation, along with influence of several antioxidative enzymes. These results show the application possibility of focused microarray analysis on the investigation of nonalcoholic steatohepatitis development caused by the multifactorial mechanism. Further study will enable elucidation of steatohepatitis development mechanism.
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